Reishi or Ganoderma and its Effects on HIV - AIDS
Here is a fragment of the Webinar Video where Data Dr. Lim Siow Jin talks about this topic.
According to studies there is scientific information on its application in people with this virus, here is the information:
Activity against the Immunodeficiency Virus (HIV) Currently and worldwide there are an estimated 42 million people living with HIV or AIDS worldwide and more than 3 million die each year from AIDS-related illnesses.
Acquired Immunodeficiency Syndrome (AIDS), caused by HIV infection, has become an important social and medical health problem. Anti-HIV therapy by nucleoside analogs, such as 30'-azidothymidine, is the approach considered to be mainly effective for the treatment of acquired immunodeficiency syndrome according to studies already carried out.
These agents are potent inhibitors of HIV reverse transcriptase (RT) and proteases.
However, the appearance of variants of the HIV virus that become resistant to drugs and their toxicity severely limits the long-term efficacy of these drugs.
Recent studies have indicated that many natural products are active as anti-HIV agents. These compounds belong to a wide range of different structural classes, viz. coumarins, flavonoids, tannins, alkaloids, lignins, terpenes, naphtho and anthraxquinones and polysaccharides.
Different in vitro studies indicated that various triterpenoids in Reishi showed potent inhibitory activity against HIV. Lucidenic acid O and lucidenic lactone, isolated from the fruiting body of Ganoderma lucidum, not only inhibit the activities of calf DNA polymerase alpha and DNA polymerase beta derata, but also against HIV-1 reverse transcriptase.
Ganoderiol F and ganodermanontriol isolated from the fruiting bodies of Ganoderma lucidum are active against the growth of HIV-1 with an IC100 of 7.8 µg/ml.
Ganoderic acid B and ganoderiol B showed potent inhibitory effect on HIV protease, with an IC50 concentration value of 0.17 mM.
Other triterpenoids including ganoderic acid C1, 3beta-5alpha-dihydroxy-6beta-methoxyergosta-7, 22-diene, beta-ganoderic acid, ganoderic acid H, and ganoderiol A have moderate activity against HIV-1 protease with IC50 concentrations 0.17–0.23mM.
Additionally, beta-ganoderic acid, lucidumol B, ganodermandiol, ganodermanontriol, and ganolucidic acid A demonstrated significant action against the activity of HIV-1 virus proteases with IC50 values of 20, 59, 90, 70, and 70 mM, respectively.
Ganoderic Acid A, B and C1 have lower inhibitory activity against HIV protease, with IC50 values of 140-430 mM. There seems to be a structure-activity relationship of triterpenoid showing anti-HIV protease activity. The C3, C24, or C25 atoms are vital for anti HIV activity. It is recommended if you suffer from this virus that you consume pure Ganoderma spores, which are very effective in reducing the effects of HIV and eliminating it completely with high doses of Ganoderma lucidum.
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